Increased autoreactivity and maturity of EBI2+ antibody-secreting cells from nasal polyps
Bai J, Kato A, Hulse K, Wechsler J, Gujar V, Poposki J, Harmon R, Iwasaki N, Wang B, Huang J, Stevens W, Conley D, Welch K, Kern R, Peters A, Eisenbarth S, Schleimer R, Tan B. Increased autoreactivity and maturity of EBI2+ antibody-secreting cells from nasal polyps. JCI Insight 2024, 9: e177729. PMID: 39253973, PMCID: PMC11385095, DOI: 10.1172/jci.insight.177729.Peer-Reviewed Original ResearchConceptsAntibody-secreting cellsGene Ontology biological processesSingle-cell RNA-seq analysisApoptosis pathwayNumbers of antibody-secreting cellsAnti-dsDNA IgGPlasma cell differentiationBiological processesCell differentiationNasal polypsGenesMolecular characteristicsNF-kBProliferative cellsMolecular featuresCellsAnti-double-stranded DNAIgG antibody-secreting cellsEBI2B cellsXBP1Recurrent NPElevated numbersDNAIncreased autoreactivity
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