Structural study for substrate recognition of human N‐terminal glutamine amidohydrolase 1 in the arginine N‐degron pathway
Kang J, Park J, Lee J, Jang J, Han B. Structural study for substrate recognition of human N‐terminal glutamine amidohydrolase 1 in the arginine N‐degron pathway. Protein Science 2024, 33: e5067. PMID: 38864716, PMCID: PMC11168063, DOI: 10.1002/pro.5067.Peer-Reviewed Original ResearchConceptsN-degron pathwaySubstrate recognitionN-degronSubstrate-binding conformationHalf-life of proteinsProtein degradation machineryTargeted protein therapyDegradation machinerySubstrate specificityProtein regulationBackbone of proteinsGln residuesCharged residuesNT residuesDegradation systemProteinBiochemical analysisResiduesPathwayStructural studiesGlnProtein therapyArginineSide chainsShed light
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