Gender differences in the associations of circadian function with cognition among older persons with sleep disturbances
Pan Y, Cho G, Doyle M, Polisetty L, Burzynski C, Iannone L, Knauert M, Yaggi H, Gill T, Miner B. Gender differences in the associations of circadian function with cognition among older persons with sleep disturbances. Alzheimer's & Dementia 2024, 20: e089617. PMCID: PMC11716249, DOI: 10.1002/alz.089617.Peer-Reviewed Original ResearchMoCA scoresOlder adultsCognitive functionCommunity-dwelling older adultsCommunity-living adultsSleep disturbanceMontreal Cognitive AssessmentNo significant associationSleep-related factorsDays of actigraphyOlder personsActivity countsGender differencesPearson correlation coefficientMinority raceScore associationsInvestigate gender differencesCognitive AssessmentCircadian functionSlow wave sleepSignificant associationTotal sleep timeMoCANight of polysomnographyOlder menLower slow wave sleep and rapid eye‐movement sleep are associated with brain atrophy of AD‐vulnerable regions
Cho G, Mecca A, Buxton O, Liu X, Miner B. Lower slow wave sleep and rapid eye‐movement sleep are associated with brain atrophy of AD‐vulnerable regions. Alzheimer's & Dementia 2024, 20: e093827. PMCID: PMC11713325, DOI: 10.1002/alz.093827.Peer-Reviewed Original ResearchInferior parietal regionsSlow wave sleepAD-vulnerable regionsAssociated with smaller volumesParietal regionsPresence of cerebral microbleedsSleep architectureAlzheimer's diseaseCerebral microbleedsIncreased risk of Alzheimer's diseaseProportion of timeRisk of Alzheimer's diseaseBaseline cognitive functionLobar cerebral microbleedsModifiable risk factorsAssociated with lower volumesAssociated with brain atrophyBaseline sleep architectureSleep architecture variablesSleep deficiencyAssociated with ADFalse discovery rateAtherosclerosis RiskAD pathogenesisEye-movement sleepLower slow wave sleep and rapid eye‐movement sleep are associated with brain atrophy of AD‐vulnerable regions
Cho G, Mecca A, Buxton O, Liu X, Miner B. Lower slow wave sleep and rapid eye‐movement sleep are associated with brain atrophy of AD‐vulnerable regions. Alzheimer's & Dementia 2024, 20: e089369. PMCID: PMC11716384, DOI: 10.1002/alz.089369.Peer-Reviewed Original ResearchInferior parietal regionsSlow wave sleepAD-vulnerable regionsAssociated with smaller volumesParietal regionsPresence of cerebral microbleedsSleep architectureAlzheimer's diseaseCerebral microbleedsIncreased risk of Alzheimer's diseaseProportion of timeRisk of Alzheimer's diseaseBaseline cognitive functionLobar cerebral microbleedsModifiable risk factorsAssociated with lower volumesAssociated with brain atrophyBaseline sleep architectureSleep architecture variablesSleep deficiencyAssociated with ADFalse discovery rateAtherosclerosis RiskAD pathogenesisEye-movement sleep1030 APOE Genotype and Sleep Architecture
Cho G, Buxton O, Pan Y, Miner B. 1030 APOE Genotype and Sleep Architecture. Sleep 2024, 47: a442-a443. DOI: 10.1093/sleep/zsae067.01030.Peer-Reviewed Original ResearchInverse linear trendAPOE4 carrier statusCarrier statusNon-carriersAPOE4 genotypeBurden of Alzheimer's diseaseSlow wave sleepSleep Heart Health StudyAllele carrier statusAPOE4 carriersAPOE4 alleleHealth StudyAssociated with timeReduced sleep qualityGenetic risk factorsLinear regression modelsLinear trendMarital statusIncreasing burdenSleep architectureNon-significant resultsSleep qualityIn-homeEducational attainmentSleep duration
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