Reduced Frontoparietal Activity in Schizophrenia Is Linked to a Specific Deficit in Goal Maintenance: A Multisite Functional Imaging Study
Poppe AB, Barch DM, Carter CS, Gold JM, Ragland JD, Silverstein SM, MacDonald AW. Reduced Frontoparietal Activity in Schizophrenia Is Linked to a Specific Deficit in Goal Maintenance: A Multisite Functional Imaging Study. Schizophrenia Bulletin 2016, 42: 1149-1157. PMID: 27060129, PMCID: PMC4988742, DOI: 10.1093/schbul/sbw036.Peer-Reviewed Original ResearchConceptsHealthy controlsGroup differencesImaging studiesWhole-brain voxelwise analysisPosterior parietal lobeFunctional imaging studiesMiddle frontal gyrus activityAttention network dysfunctionMinutes of scanningSpecific deficitsSignificant group differencesSpecific performance deficitsNetwork dysfunctionFunctional magnetic resonance imaging (fMRI) scannerParietal lobeSchizophreniaVoxelwise analysisDisorganization symptomsMagnetic resonance imaging (MRI) scannerPatientsReduced activityScan lengthDeficitsExecutive functionPerformance deficits
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