Joon Sung Park, PhD
Associate Research Scientist in PharmacologyCards
About
Research
Publications
2024
Structural study for substrate recognition of human N‐terminal glutamine amidohydrolase 1 in the arginine N‐degron pathway
Kang J, Park J, Lee J, Jang J, Han B. Structural study for substrate recognition of human N‐terminal glutamine amidohydrolase 1 in the arginine N‐degron pathway. Protein Science 2024, 33: e5067. PMID: 38864716, PMCID: PMC11168063, DOI: 10.1002/pro.5067.Peer-Reviewed Original ResearchConceptsN-degron pathwaySubstrate recognitionN-degronSubstrate-binding conformationHalf-life of proteinsProtein degradation machineryTargeted protein therapyDegradation machinerySubstrate specificityProtein regulationBackbone of proteinsGln residuesCharged residuesNT residuesDegradation systemProteinBiochemical analysisResiduesPathwayStructural studiesGlnProtein therapyArginineSide chainsShed lightReaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase
Xie S, Wang Y, Morton C, Metcalfe R, Dogovski C, Pasaje C, Dunn E, Luth M, Kumpornsin K, Istvan E, Park J, Fairhurst K, Ketprasit N, Yeo T, Yildirim O, Bhebhe M, Klug D, Rutledge P, Godoy L, Dey S, De Souza M, Siqueira-Neto J, Du Y, Puhalovich T, Amini M, Shami G, Loesbanluechai D, Nie S, Williamson N, Jana G, Maity B, Thomson P, Foley T, Tan D, Niles J, Han B, Goldberg D, Burrows J, Fidock D, Lee M, Winzeler E, Griffin M, Todd M, Tilley L. Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nature Communications 2024, 15: 937. PMID: 38297033, PMCID: PMC10831071, DOI: 10.1038/s41467-024-45224-z.Peer-Reviewed Original ResearchConceptsX-ray crystallographic studiesStructure-activity relationshipSynthetically accessible scaffoldMass spectrometryTargeted mass spectrometryAccessible scaffoldInhibitor adductX-rayMechanism of actionAmino acid starvation responseMammalian cell toxicityPro inhibitorsAdductsLow mammalian cell toxicityParasite culturesDeploying drugsInhibitor classCell toxicityReactionPlasmodiumResistance developmentLow propensityIncreased resistanceInhibitionSpectrometry